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Antihistamine medications are used to relieve or alleviate the red swelling skin, itching, stinging and burning sensation associated with hives rash. It works by counter reacting to the effects of histamine. Moreover, all the antihistamine drugs, both over-the-counter and the prescription antihistamine drugs can cause side effects like drowsiness, blurry vision, stomach 
If you are sensitive to allergen such as ragweed pollen or chemical such as paint, once contacted it will precipitate your immune system into releasing histamines from the mast cells and attaches to the receptors in the surrounding blood vessels causing them to enlarge. Histamine will also bind to other receptors, which causes redness, swelling |
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